AMKdose is an interactive application, freely available, for amikacin initial dosage optimization. AMKdose can be useful for initial amikacin dosing selection when no individual pharmacokinetic information is available.
This app is based in population pharmacokinetics model developed in adult patients without severe renal impairment (<30 mL/min) and mostly with hypoalbuminemia (75%). The model has been externally validated and implemented in R with shiny and Rmarkdown for the interactive setting.
More information regarding the PopPK model development and how to use AMKdose is available under the “ReadMe” tab of the application and here: Perez-Blanco JS, Saez Fernandez EM, Lanao J, Calvo MV, Martin-Suarez A. Amikacin initial dosage in patients with hypoalbuminemia: an interactive tool based on a population pharmacokinetic approach. 2020. Journal of Antimicrobial Chemotherapy, DOI: 10.1093/jac/dkaa158